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CONFERENCE ON THE ECONOMICS AND FINANCE OF HEALTHCARE AND MEDICINE

April 25, 2025

 

Sponsored by:

The Wells Fargo Advisors Center for Finance and Accounting Research 

WashU Olin Business School and its Wells Fargo Advisors Center for Finance and Accounting Research (WFA-CFAR) cordially invite you to attend the Conference on the Economics and Finance of Healthcare and Medicine at WashU, April 25, 2025. The conference will highlight research at the intersection of healthcare/medicine and economics/finance.  

We look forward to seeing you at the conference!

CONFERENCE COMMITTEE

Barton Hamilton

Anjan Thakor

 

 

Details

April 25, 2025
Olin Business School at Washington University in Saint Louis

Charles F. Knight Executive Education & Conference Center, Snow Way Drive, St. Louis, MO, USA

Snow Way Drive
63130 St. Louis MO
United States

Keynote Speaker

Andrew Lo

Charles E. and Susan T. Harris Professor of Finance
MIT Sloan School of Management
  • alo.mit.edu
  • Andrew Lo

    Professor Lo's current research spans five areas: evolutionary models of investor behavior and adaptive markets, systemic risk and financial regulation, quantitative models of financial markets, financial applications of machine-learning techniques and secure multi-party computation, and healthcare finance.  Recent projects include: deriving risk aversion, loss aversion, probability matching, and other behaviors as emergent properties of evolution in stochastic environments; quantifying the financial consequences of ESG and other forms of impact investing on investment performance; proposing new funding models for fusion energy; and developing new statistical tools for predicting clinical trial outcomes, incorporating patient preferences into the drug approval process, and accelerating biomedical innovation via novel financing and business structures.  He is currently an advisor to the Journal of Investment Management and the Journal of Portfolio Management.

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Presenters

Gaurab Aryal

Associate Professor, Department of Economics
Boston University
  • sites.google.com
  • Gaurab Aryal

    Vauling Pharmaceutical Innovation

    Gaurab Aryal, Federico Ciliberto, Leland E. Farmer, Ekaterina Khmelnitskaya

    We propose a methodology to estimate the market value of pharmaceutical drugs. Our approach combines an event study with a model of discounted cash flows and uses stock market responses to drug development announcements to infer the values. We estimate that, on average, a successful drug is valued at $1.62 billion, and its value at the discovery stage is $64.3 million, with substantial heterogeneity across major diseases. Leveraging these estimates, we also determine the average drug development costs at various stages. Furthermore, we explore applying our estimates to design policies that support drug development through drug buyouts and cost-sharing agreements.

    Read more

Dragana Cvijanovic

Hospitality Valuation Services Professor of Hotel Finance and Real Estate
Cornell University
Dragana Cvijanovic
  • Dragana Cvijanovic

    Childhood Mental Health and Long-run Financial Outcomes

    Dragana Cvijanovic, Moritz Wiedemann, Atlas Wu

    We investigate the relationship between childhood mental health conditions and financial outcomes later in life. We find that individuals with childhood mental health conditions are significantly less likely to hold any assets, accumulate fewer total assets both unconditionally and conditionally on asset ownership, and are less likely to be homeowners over the life cycle. They also tend to accumulate more debt, and in particular more non-mortgage debt. These results are largely driven by white and male demographic groups. Financial literacy mitigates most of these effects. Childhood mental health is also linked to a lower likelihood of overconfidence, shorter life span expectancy and financial planning horizons, more pessimistic economic outlook, and reduced cognitive abilities, all of which may jointly explain the observed differences in financial outcomes.

     

    Read more

Meghan Esson

Aegon Transamerica RMI Fellowship and Assistant Professor
University of Iowa
  • tippie.uiowa.edu
  • Meghan Esson

    Firm Investment in the Face of Tail Risk: Evidence From Hospitals

    Meghan Esson and Jingshu Luo

    We examine how organizations navigate investment decisions when confronted with tail risk -- the small possibility of extreme financial loss. We focus on hospital investments in trauma centers faced with medical malpractice risk. We focus on hospitals for three reasons: first, medical malpractice insurance inherently leaves hospitals exposed to substantial tail risk; second, the consequential financial stakes of medical liability for hospitals are quite large; and third, while trauma centers are financially beneficial, they are also exceptionally susceptible to tail risk given the critical nature of their services. For identification, we exploit the staggered adoption of caps on non-economic damages across states from 1991 to 2011, treating this as a quasi-random modulation of tail risk. These caps impose a ceiling on potential awards in malpractice lawsuits, thereby attenuating the tail risk. Employing a staggered synthetic control methodology, we find a 25% increase in the likelihood that a hospital has a trauma center following the reduction of tail risk. This effect is predominantly driven by non-profit hospitals and new investments (i.e., trauma center openings) rather than disinvestment (i.e., decrease in trauma center closures), indicating a one-sided response to decreased tail risk. We demonstrate that this increased presence of trauma centers is associated with a 3% reduction in traffic fatalities, with more pronounced effects in areas prone to mass casualty incidents. The timing of health improvements aligns closely with the increase in trauma centers, suggesting a direct link between hospital investment decisions and improved public health outcomes.

    Read more

Christoph Herpfer

Assistant Professor of Business Administration, Finance
University of Virginia
  • www.darden.virginia.edu
  • Christoph Herpfer

    Corporate Behavior When Running the Firm for Stakeholders: Evidence from Hospitals

    Christoph Herpfer, Jianzhang Lin, Gonzalo Maturana

    We study how stakeholder orientation impacts firm management and performance. We exploit state-level law changes governing the conversion of hospitals from nonprofit to for-profit and find that for-profit orientation reduces hospital spending on emergency rooms and Medicaid patients,while increasing focus on revenue and affecting investment decisions. Consistent with spillovers, nonprofit hospitals located near converting hospitals experience increased emergency room visits and expenditures. We investigate governance channels that align corporate behavior with stake-holders and find that converted for-profit hospitals adjust their boards by replacing MDs with MBAs, and that the tax code is a major source of governance for nonprofits.

    Read more

Ryan McDevitt

Professor, Economics
Duke University

Alex Priest

Assistant Professor, Finance
University of Rochester
  • simon.rochester.edu
  • Alex Priest

    Overbilling and Killing? An Examination of the Skilled Nursing Industry

    John M. Griffin and Alex Priest

    Skilled Nursing Facility (SNF) systems that provided excess rehab therapy just above revenue thresholds quickly begin upcoding previously unidentified comorbidities under the new PDPM billing regime. Patients at these opportunistic systems develop more than 50% greater preventable conditions and have twice as many verified reviews indicating abuse. Opportunistic systems mask adverse outcomes through underreporting to CMS. Instrumental variable estimates indicate that opportunistic SNF systems are responsible for an additional 35,000 hospitalizations and 30,000 deaths since PDPM was enacted, while overbilling Medicare $4.3 billion. Opportunistic SNF systems are spreading with more than 2.5 times the acquisition rate of accurate billing systems.

    Read more

Richard Thakor

Associate Professor, Finance
University of Minnesota
  • carlsonschool.umn.edu
  • Richard Thakor

    When Private Equity Comes to Town: The Local Economic Consequences of Rising Healthcare Costs

    Cyrus Aghamolla, Jash Jain, Richard T. Thakor

    We examine the effect of increased healthcare costs on local economic conditions. We use private equity buyouts of hospital systems as a shock to the healthcare costs faced by firms in affected areas. We provide evidence that private equity buyouts of hospital systems result in higher healthcare insurance premiums paid by firms, and such rises in premiums lead to higher business bankruptcies, an increase in business loan volume, slower employment and establishment growth, and reduced innovative output. The effects are more pronounced in areas with less competitive hospital markets, higher labor intensity, and fewer insurers providing coverage.

    Read more

Pietro Veronesi

Deputy Dean for Faculty and Sherman and Vivian Chao Distinguished Service Professor of Finance
The University of Chicago Booth School of Business
  • www.chicagobooth.edu
  • Pietro Veronesi

    On the Economic Infeasibility of Personalized Medicine, and a Solution

    Marina Chiara Garassino, Kunel Odunsi, Marciano Siniscalchi, Pietro Veronesi

    Technological advances and genomic sequencing opened the road to personalized medicine, specialized therapies targeted to patients displaying specific molecular alterations. In oncology, targeted therapies are now available even for alterations affecting less than 1% of lung cancer patients. Summing across alterations, targeted therapies are available for over 50% of patients and greatly contributed to increasing their life expectancy. In an investment model of drug development, we show that the current infrastructure requiring experimentation and FDA approval of each therapy will fail as researchers identify increasingly rarer alterations. We also show that AI-based drug discovery is instead viable under the paradigm shift in which the FDA approves the process for personalized drug discovery rather than individual therapies.

    Read more

Discussants

Cecilia Diaz-Campo

Assistant Professor, Economics
WashU Olin Business

Jon Garfinkel

Henry B. Tippie Research Professor in Finance
University of Iowa

Nicolae Garleanu

H. Frederick Hagemann Jr. Professor of Finance
WashU Olin Business

Riley League

Assistant Professor of Finance
University of Illinois Urbana-Champaign

Katharina Lewellen

Professor of Finance
Dartmouth

Tong Liu

Judy C. Lewent (1972) and Mark Shapiro Career Development Assistant Professor of Finance
MIT Sloan

Noah Lyman

Assistant Professor, Finance
Warwick Business School

Nicholas Papageorge

Broadus Mitchell Associate Professor of Economics and Associate Director of the Poverty and Inequality Research Lab
Johns Hopkins University

Session Chairs

Patrick Aguilar

Professor of Practice of Organizational Behavior and Managing Director of Health
WashU Olin Business

Barton Hamilton

Robert Brookings Smith Distinguished Professor of Economics, Management & Entrepreneurship and Academic Advisor Center for Experiential Learning
WashU Olin Business School

Lamar Pierce

Beverly and James Hance Professor of Strategy
WashU Olin Business

Stephen Ryan

Myron Northrop Professor of Economics and Senior Associate Dean of Doctoral Programs
WashU Olin Business

Papers

Childhood Mental Health and Long-run Financial Outcomes

Dragana Cvijanovic, Moritz Wiedemann, Atlas Wu

We investigate the relationship between childhood mental health conditions and financial outcomes later in life. We find that individuals with childhood mental health conditions are significantly less likely to hold any assets, accumulate fewer total assets both unconditionally and conditionally on asset ownership, and are less likely to be homeowners over the life cycle. They also tend to accumulate more debt, and in particular more non-mortgage debt. These results are largely driven by white and male demographic groups. Financial literacy mitigates most of these effects. Childhood mental health is also linked to a lower likelihood of overconfidence, shorter life span expectancy and financial planning horizons, more pessimistic economic outlook, and reduced cognitive abilities, all of which may jointly explain the observed differences in financial outcomes.

Competition and Fraud in Healthcare

Ryan McDevitt

Corporate Behavior When Running the Firm for Stakeholders: Evidence from Hospitals

Christoph Herpfer, Jianzhang Lin, Gonzalo Maturana

We study how stakeholder orientation impacts firm management and performance. We exploit state-level law changes governing the conversion of hospitals from nonprofit to for-profit and find that for-profit orientation reduces hospital spending on emergency rooms and Medicaid patients,while increasing focus on revenue and affecting investment decisions. Consistent with spillovers, nonprofit hospitals located near converting hospitals experience increased emergency room visits and expenditures. We investigate governance channels that align corporate behavior with stake-holders and find that converted for-profit hospitals adjust their boards by replacing MDs with MBAs, and that the tax code is a major source of governance for nonprofits.

Firm Investment in the Face of Tail Risk: Evidence From Hospitals

Meghan Esson and Jingshu Luo

We examine how organizations navigate investment decisions when confronted with tail risk -- the small possibility of extreme financial loss. We focus on hospital investments in trauma centers faced with medical malpractice risk. We focus on hospitals for three reasons: first, medical malpractice insurance inherently leaves hospitals exposed to substantial tail risk; second, the consequential financial stakes of medical liability for hospitals are quite large; and third, while trauma centers are financially beneficial, they are also exceptionally susceptible to tail risk given the critical nature of their services. For identification, we exploit the staggered adoption of caps on non-economic damages across states from 1991 to 2011, treating this as a quasi-random modulation of tail risk. These caps impose a ceiling on potential awards in malpractice lawsuits, thereby attenuating the tail risk. Employing a staggered synthetic control methodology, we find a 25% increase in the likelihood that a hospital has a trauma center following the reduction of tail risk. This effect is predominantly driven by non-profit hospitals and new investments (i.e., trauma center openings) rather than disinvestment (i.e., decrease in trauma center closures), indicating a one-sided response to decreased tail risk. We demonstrate that this increased presence of trauma centers is associated with a 3% reduction in traffic fatalities, with more pronounced effects in areas prone to mass casualty incidents. The timing of health improvements aligns closely with the increase in trauma centers, suggesting a direct link between hospital investment decisions and improved public health outcomes.

On the Economic Infeasibility of Personalized Medicine, and a Solution

Marina Chiara Garassino, Kunel Odunsi, Marciano Siniscalchi, Pietro Veronesi

Technological advances and genomic sequencing opened the road to personalized medicine, specialized therapies targeted to patients displaying specific molecular alterations. In oncology, targeted therapies are now available even for alterations affecting less than 1% of lung cancer patients. Summing across alterations, targeted therapies are available for over 50% of patients and greatly contributed to increasing their life expectancy. In an investment model of drug development, we show that the current infrastructure requiring experimentation and FDA approval of each therapy will fail as researchers identify increasingly rarer alterations. We also show that AI-based drug discovery is instead viable under the paradigm shift in which the FDA approves the process for personalized drug discovery rather than individual therapies.

Overbilling and Killing? An Examination of the Skilled Nursing Industry

John M. Griffin and Alex Priest

Skilled Nursing Facility (SNF) systems that provided excess rehab therapy just above revenue thresholds quickly begin upcoding previously unidentified comorbidities under the new PDPM billing regime. Patients at these opportunistic systems develop more than 50% greater preventable conditions and have twice as many verified reviews indicating abuse. Opportunistic systems mask adverse outcomes through underreporting to CMS. Instrumental variable estimates indicate that opportunistic SNF systems are responsible for an additional 35,000 hospitalizations and 30,000 deaths since PDPM was enacted, while overbilling Medicare $4.3 billion. Opportunistic SNF systems are spreading with more than 2.5 times the acquisition rate of accurate billing systems.

Valuing Pharmaceutical Innovation

Gaurab Aryal, Federico Ciliberto, Leland E. Farmer, Ekaterina Khmelnitskaya

We propose a methodology to estimate the market value of pharmaceutical drugs. Our approach combines an event study with a model of discounted cash flows and uses stock market responses to drug development announcements to infer the values. We estimate that, on average, a successful drug is valued at $1.62 billion, and its value at the discovery stage is $64.3 million, with substantial heterogeneity across major diseases. Leveraging these estimates, we also determine the average drug development costs at various stages. Furthermore, we explore applying our estimates to design policies that support drug development through drug buyouts and cost-sharing agreements.

When Private Equity Comes to Town: The Local Economic Consequences of Rising Healthcare Costs

Cyrus Aghamolla, Jash Jain, Richard T. Thakor

We examine the effect of increased healthcare costs on local economic conditions. We use private equity buyouts of hospital systems as a shock to the healthcare costs faced by firms in affected areas. We provide evidence that private equity buyouts of hospital systems result in higher healthcare insurance premiums paid by firms, and such rises in premiums lead to higher business bankruptcies, an increase in business loan volume, slower employment and establishment growth, and reduced innovative output. The effects are more pronounced in areas with less competitive hospital markets, higher labor intensity, and fewer insurers providing coverage.

 

Local Hotel Information

Le Méridien St. Louis, Clayton 

Approximately 1.7 miles from the Charles F. Knight Center/Washington University campus.

7730 Bonhomme Avenue, St. Louis, MO 63105.  Phone: (314) 863-0400

The Chesire
Approximately 1.9 miles from the Charles F. Knight Center/Washington University Campus. 

6300 Clayton Road, St. Louis, MO 63117. Phone: (314) 647-7300; Email: cheshire@cheshirestl.com 

Residence Inn, Clayton 

Approximately 2.2 miles from the Charles F. Knight Center/Washington University campus.

8125 Forsyth Blvd, Clayton, MO 63105.  Phone: (314) 639-9030

The Ritz-Carlton, Clayton
Approximately 1 mile from the Charles F. Knight Center/Washington University Campus. 

100 Carondelet Plaza, St. Louis, MO 63105. Phone: (314) 863-6300

AC Hotel St. Louis, Central West End 

Approximately 2.9 miles from the Charles F. Knight Center/Washington University campus.

215 York Ave, St. Louis, MO 63108. Phone: (314) 887-4849 

Contact

Kristen Jones
Operations Manager

Wells Fargo Advisors Center for Finance & Accounting Research
WashU Olin Business 

Email: kristen.jones@wustl.edu 

Sponsors

Conference sponsored by the Wells Fargo Advisors Center for

Finance and Accounting Research at

WashU Olin Business School

ORGANIZERS:

 

Barton Hamilton

Robert Brookings Smith Distinguished Professor of Entrepreneurship, and Research Director, Koch Center for Family Enterprise
WashU Olin Business
Barton Hamilton

Anjan Thakor

John E. Simon Professor of Finance, and Director of the WFA Center for Finance and Accounting Research
WashU Olin Business
Anjan Thakor

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